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Advise pregnant women of potential for serious adverse reactions related to these substrates for drugs that are sensitive to minimal concentration changes. Monitor patients for signs of bleeding. Dose Modifications and Discontinuations: ARs led to dosage reductions in 4. Patients: fatigue (29; 1. Patients: best online samsca hemoglobin decreased (42; 9), platelet count decreased (32; 15), creatinine increased (30; 1. Drug InteractionsStrong CYP3A Inhibitors: Concomitant use with Jaypirca increased pirtobrutinib systemic exposure, which may increase risk of recurrence. Avoid use of ketoconazole. Efficacy and safety results were consistent with the overall safety profile, without evidence of new or worsening toxicity signals.

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